Papillary Endometrial Carcinoma: 1 Case Report and Review of the Literature

Papillary endometrial carcinoma is a rare and aggressive form of uterine cancer, distinct from the more common endometrioid types. It occurs mainly in post-menopausal women, in the absence of hyperestrogenism. Histologically, it is characterized by a complex papillary architecture and marked nuclear atypia. Diagnosis is based on histology and immunohistochemistry, enabling differentiation from serous carcinoma. Treatment is based on a multimodal approach combining surgery, chemotherapy and sometimes radiotherapy. Due to its aggressive nature, the prognosis remains guarded, with a high risk of recurrence and metastasis. Recognition of this entity is helping to optimize management and steer research towards more targeted therapies.