Assessment of the Development of Gastrointestinal Cancers in Individuals with a History of Cholecystectomy and Gallstone

Introduction: Gastrointestinal malignancies are dangerous diseases that many investigations about them have been done. Several factors have been discovered that increases their incidence. This study aims to introduce a new risk factor for GI malignancies occurrence. Methods and material: In a case-controlled study documents of patients in the hospital were investigated for the history of cholecystectomy and presence of gall stone in GI cancer. Results: Odds ratio for patients with a history of cholecystectomy compared to normal cases was 2.67. Also, the odds ratio for patients with the presence of gallstone was 9.65. Conclusion: The result of this study confirms the increased risk of cancer in patients with gall bladder abnormalities. This may suggest a common etiology for the occurrence of GI cancers. Also, sustained flows of bile may disturb the GI lumen and predispose it to develop cancer.