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Impact of Three-dimensional-printed Skull Inserts of Different Thickness on Magnetic Resonance-guided Focused Ultrasound Heating in a Head Phantom

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Observational analysis evaluated FUS transmission through various thicknesses of skull inserts, suggesting impacts on temperature elevation.

FUS transmission was impaired with thicker skull inserts, highlighting a challenge in achieving effective brain tissue ablation.
A significant temperature decrease was observed with 2-mm inserts, while tissue ablation was possible with 1-mm inserts.
Focal temperature was measured using thermometry within a 3T magnetic resonance imaging scanner.
The findings indicate the potential for 3D-printed skull inserts to improve ultrasound treatments, though further validation is needed.

Antoniou et al. (2025) studied this question.

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Observational analysis evaluated FUS transmission through various thicknesses of skull inserts, suggesting impacts on temperature elevation.