Partial Molar Pregnancy with Coexistent Normal Appearing Singleton Foetus with Normal Karyotype - A Challenging Rare Clinical Entity

A BSTRACT Partial molar pregnancy is a rare clinical entity usually associated with an abnormal foetus with triploid karyotype and with a large cystic placenta. The incidence of partial mole with the normal diploid foetus is extremely rare. We present a case of placentomegaly with cystic changes, detected during 1 st -trimester obstetric scan with a diploid karyotype foetus. Further evaluation by serum beta-human chorionic gonadotropin, alpha-fetoprotein, imaging for foetal anomalies, and karyotyping added to the diagnostic and clinical dilemma as foetus showed no obvious abnormality with normal diploid karyotype. The patient was counselled and placed on close monitoring. At 23 rd weeks gestation, she clinically presented with inevitable abortion and underwent spontaneous mid-trimester abortion with placenta showing features of partial molar changes on histopathological examination.