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September 10, 2025Frontiers in Animal ScienceOpen Access

Whole blood RNA-seq analysis reveals the immunomodulatory effects of a supplemental multi-strain direct-fed microbial in the diet of newly weaned beef steers1

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Beef steers fed a multi-strain microbial additive showed differential expression of genes related to immune functions and inflammation.
Forty Angus crossbred steers were used over a 56-day period, with significant upregulation of 21 genes in the treatment group.
Gene ontology analysis indicated pathways related to inflammatory response and cytokine secretion were enriched in steers fed the microbial additive.
Findings suggest that multi-strain microbials could enhance immune health and stress resilience in newly weaned beef cattle.

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Observational analysis reveals impact of a multi-strain microbial additive on immune function in beef steers, highlighting its potential benefits.

Ajiboye et al. (2025) studied this question.

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Observational analysis reveals impact of a multi-strain microbial additive on immune function in beef steers, highlighting its potential benefits.