Features of hypogonadism in men with obesity

The relationship between testosterone production and obesity has been found in numerous epidemiological studies. The main feature of obesity in males lies in the fact that it is abdominal obesity, i.e. deposition of adipose tissue mainly in the abdominal area, which has the consequence of affecting sex hormones metabolism. Androgen aromatization, leptin resistance, testosterone deposition, and the influence of other comorbid factors all contribute to the formation of bidirectional relationship between obesity and low testosterone levels. The increased interest in this problem has been observed in recent years, and there is data confirming the link between excess body weight and decreased testosterone levels in males. This latter data is presented in this published review. Meanwhile, reduction of body fat mass can be considered as a proposed approach to correcting hypogonadism associated with metabolic disorders, since hypogonadism in males with metabolic disorders is potentially reversible.