Non-alcoholic fatty liver disease, metabolic dysfunction and sarcopenia

The aging of the population is accompanied by an increase in the number of chronic diseases, including NAFLD, metabolic syndrome, diabetes mellitus, prediabe tes, and sarcopenia. Insulin resistance, chronic inflammation, and metabolic disorders are common pathogenetic mechanisms linking all of these diseases. Sarcopenia, char acterized by loss of muscle mass and function, exacerbates metabolic disorders and increases the risk of developing prediabetes into type 2 diabetes mellitus. It should be noted that the effect of sarcopenic obesity on the progression of glycemic status, as determined by fasting plasma glucose and glycated hemoglobin, may be more pro nounced than the effect of sarcopenia alone or obesity alone. In addition, patients with diabetes and sarcopenia have certain changes in the composition of muscle fibers, which requires an integrated approach to diagnosis, prevention, and treatment.