Aortic dissection caused by the mutation of the ACTA2 gene: report of a case

Alterations in smooth muscle contractility can be produced by mutations in the ACTA2 gene. This autosomal dominant inheritance disease can be manifested as a thoracic aortic dissection. Most of the time, early diagnosis and treatment are required due to the high mortality of this clinical entity. In some cases, genetic analysis plays a decisive role. We expose the clinical case of a 45-year-old woman with a mutation in a variant of the ACTA2 gene, who presents a spontaneous aortic dissection associated with a transient ischemic attack.