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September 10, 2025Scientific ReportsOpen Access

Scan-rescan reliability assessment of brain volumetric analysis across scanners and software solutions

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Authors

EBEva Bürkle ANAhmad NazzalKonrad-Adenauer-Stiftung ADAlexander DebolskiUniversity Children's Hospital Tübingen

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Implication

This study evaluates the reliability of brain volume measurements across different scanners and software, highlighting significant impacts on neurodegenerative disease screening.

Key Points

Significant effects of software and scanner on brain volume measures were found, with software having a stronger effect.
Median percentage of coefficient of variation across scanners was below 0.2% for AssemblyNet and AIRAscore for gray and white matter.
No systematic difference was observed in the Bland-Altman analysis, but limits of agreement varied widely between methods.
Using consistent software and scanner combinations is crucial for reliable monitoring of brain volume changes.

Cite This Study

Bürkle et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23554b1d3bfb60efa53 https://doi.org/10.1038/s41598-025-15283-3

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Implication

This study evaluates the reliability of brain volume measurements across different scanners and software, highlighting significant impacts on neurodegenerative disease screening.

Scan-rescan reliability assessment of brain volumetric analysis across scanners and software solutions

Discussion

Member takes

Implication

Key Points

Cite This Study

Scan-rescan reliability assessment of brain volumetric analysis across scanners and software solutions

Discussion

Member takes

Implication

Key Points

Cite This Study

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