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September 10, 2025Journal of Experimental & Clinical Cancer ResearchOpen Access

MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling

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Authors

MTMarta Torrecilla-ParraUnité de recherche sur les maladies cardiovasculaires et métaboliques VPVirginia PardoIMDEA Food AFAntonio C. Fuentes-FayosCedars-Sinai Medical Center

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Implication

Observational analysis shows miR-7 inhibits tumor progression in glioblastoma, indicating its dual role in autophagy regulation and energy metabolism.

Key Points

MiR-7 significantly inhibits glioblastoma tumor size and progression in a mouse model, enhancing survival rates.
In vivo studies reveal that miR-7 overexpression alters metabolism and autophagy, impacting key signaling pathways.
Bioinformatics and transcriptomics demonstrate that miR-7 regulates important genes involved in ECM remodeling.
The findings suggest that miR-7 presents a promising therapeutic target and biomarker for glioblastoma treatment.

Cite This Study

Torrecilla-Parra et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23554b1d3bfb60efaf5 https://doi.org/10.1186/s13046-025-03504-6

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Implication

Observational analysis shows miR-7 inhibits tumor progression in glioblastoma, indicating its dual role in autophagy regulation and energy metabolism.

MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling

Discussion

Member takes

Implication

Key Points

Cite This Study

MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling

Discussion

Member takes

Implication

Key Points

Cite This Study

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