A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon

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This is a Literature Review study.

Cameron Crowell; Ziwen Zhu; Y Li; María L. Varela; Quinn T. Ostrom; Patrick J. Cimino; Sohil H. Patel; Stuart N. Baker; Chetan Bettegowda; Houtan Noushmehr; Claudia L. Kleinman; Laura Canty; Gustavo Alencastro Veiga Cruzeiro; Anandani Nellan; Oren J. Becher; Tom B. Davidson; Dolores Hambardzumyan; Adam Green; Robert G. Thorne; Kelli M. Wilson; Brett Theeler; Jason V. Gregory; Peter Mathen; Nadia Biassou; Sheila McThenia; Craig Erker; Robert Galvin; Ariane Soldatos; Pedro R. Löwenstein; María G. Castro; Sadhana Jackson

doi:10.1038/s41698-025-01070-w

Key Points

Understanding therapy resistance in diffuse hemispheric glioma H3 G34-mutant is critical for improving outcomes.
The review summarizes key findings from the NIH G34-mutant symposium and relevant studies on DNA repair.
Cellular mechanisms driving tumor progression are inadequately understood, hindering effective treatment options.
The immune microenvironment plays a vital role in glioma, presenting potential pathways for therapeutic innovation.

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Implication

This review highlights therapy resistance and DNA repair mechanisms in diffuse hemispheric glioma, suggesting new treatment possibilities.

Abstract

Diffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood. Combining previous published studies with findings from the 2024 NIH G34-mutant symposium aid in summarizing translational and clinical updates on disease development, cellular repair processes, and the immune microenvironment. This collective work is meant to outline opportunities for treatment and prolonged survival.

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Crowell et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23554b1d3bfb60efb1d https://doi.org/10.1038/s41698-025-01070-w

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A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon

Key Points

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Implication

Abstract

Discussion

Cite This Study

A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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