A preliminary study of radiological characteristics of diffuse hemispheric gliomas, H3 G34-mutant

Diffuse hemispheric glioma, H3 G34-mutant (H3G34-DHG) is a rare newly proposed entity in 2021 WHO classification of central nervous system tumors. We retrospectively analysis characteristics of 10 cases of H3G34-DHG and found some certain characteristics in clinical and radiological manifestations in this entity. In most cases, absent or focally faint contrast enhancement initially suggested another diagnosis than a high-grade glioma. However, increased tumor vessels still suggested abundant tumor blood supply. Moreover, hyperintensity on CT and restricted diffusion reflected high density of tumor cells. MRS also showed extremely high metabolism active in the tumor.