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September 10, 2025Scientific ReportsOpen Access

Effect of ultrasound-microbubble exposure on acute myeloid leukemia cancer cell proteome

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Authors

JSJoelle StilwellDSDaron A. SavayaESEmmanuel H. Sakarya

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Overview

This investigation demonstrates altered proteome profiles in acute myeloid leukemia cells after ultrasound-microbubble treatment, highlighting potential therapeutic avenues.

Key Points

  • USMB significantly enhanced cell membrane permeability by approximately 37%, indicating its effectiveness.
  • Of the 6825 analyzed proteins, 78 were identified as differentially expressed, with fold changes of 0.8 or lower and 1.2 or higher.
  • Cells exposed to ultrasound and microbubbles showed significant alterations in key proteins like HMOX1, BACH1, and ANXA1, confirmed by Western blotting.
  • Gene ontology analysis revealed that differentially expressed proteins were involved in critical cellular components like the plasma membrane and exosomes.

Cite This Study

Stilwell et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23554b1d3bfb60efb83https://doi.org/10.1038/s41598-025-14727-0
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