Prospective analysis revealed high rates of multidrug resistance and metallo-beta-lactamase production in non-fermenting gram-negative bacilli, indicating urgent infection control needs.
Non-fermenting gram-negative bacilli (NFGNB) have become a new vision of serious and clinically important nosocomial infection, with a growing multidrug resistance (MDR), as well as the production of metallo-beta-lactamase (MBL), which makes their intervention in tertiary care centres difficult. This 18-month prospective research carried out in Bihar scrutinized 342 NFGNB isolates, whereby the most dominant was Pseudomonas aeruginosa. MDR was observed in 72.8 percent of isolates and it was significantly higher in people in the ICU (p < 0.001), whereas MBL was seen in 41.2 percent of strains. The highest susceptibility was shown by colistin, polymyxin B and tigecycline. Thus, the urgent need for effective antimicrobial stewardship and infection control practices is reported.
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Sinha et al. (2025) studied this question.
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