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September 10, 2025BiologyOpen Access

The Development of Horns in Bovidae and the Genetic Mechanisms Underpinning This Process

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Authors

XXXiaoli XuWYWenwen YanJGJiazhong Guo

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Overview

This review outlines horn development and genetic regulators in Bovidae, highlighting implications for breeding.

Key Points

  • Horns in Bovidae are derived from cranial neural crest cells and feature a complex structure with multiple stages of development.
  • Key genetic regulators RXFP2, FOXL2, HOXD1, and TWIST1 play crucial roles in horn morphogenesis and sexual dimorphism.
  • The review synthesizes advances in evolutionary origins and genetic regulation of horns in species such as bovines and goats.
  • Future research could leverage genetic selection or genome editing to optimize horn traits, impacting animal welfare and breeding.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23d54b1d3bfb60efe65https://doi.org/10.3390/biology14081027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis2026
  2. 2A single-cell transcriptomic atlas identifies key progenitor populations driving postnatal horn bud development in goats (Capra hircus)2026 · 1 citations
  3. 3Cranial Appendages in Ruminants: Diversity, Evolution, Development, and Molecular Basis of Horns, Pronghorns, Antlers, and Ossicones2026
  4. 4Gene expression supports a single origin of horns and antlers in hoofed mammals2024 · 4 citations
  5. 5Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep2024 · 3 citations