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April 24, 2026Communications BiologyOpen Access

A single-cell transcriptomic atlas identifies key progenitor populations driving postnatal horn bud development in goats (Capra hircus)

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Authors

XXXiaoli XuPZPeijie ZengZLZibo Liu

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Overview

Integrative analyses reveal key cellular mechanisms driving horn development in goats, highlighting evolutionary insights.

Key Points

  • This research aims to elucidate the cellular programs involved in postnatal horn bud development in goats.
  • Integrated histological, bulk, and single-cell transcriptomic analyses
  • Functional assays to assess osteogenic potential of identified progenitor cells
  • Cross-species analysis to compare horn and antler development
  • Identification of ZEB2+ progenitor mesenchymal cells initiating horn-specific osteogenesis.
  • Dermal lineage cells showed significant expansion and activation by postnatal day 7.
  • Distinct signaling interactions observed between keratinocytes and osteogenic cells promoting mineralization.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69eb07a4553a5433e34b3269https://doi.org/10.1038/s42003-026-10068-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis2026
  2. 2The Development of Horns in Bovidae and the Genetic Mechanisms Underpinning This Process2025
  3. 3Gene expression supports a single origin of horns and antlers in hoofed mammals2024 · 4 citations
  4. 4Cranial Appendages in Ruminants: Diversity, Evolution, Development, and Molecular Basis of Horns, Pronghorns, Antlers, and Ossicones2026
  5. 5Single-cell transcriptome analysis reveals elongation and ossification characteristics of antlers2025