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September 10, 2025Frontiers in Bioengineering and BiotechnologyOpen Access

Platelet-rich plasma may accelerate diabetic wound healing by modulating epithelial/endothelial-mesenchymal transition through inhibiting reactive oxygen species-mediated oxidative stress

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Authors

YLY LiSouth China Agricultural UniversityBCBiao ChengGuangdong Pharmaceutical UniversityJTJu TianNanjing University of Chinese Medicine

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Overview

Hypothesis explores platelet-rich plasma's role in reducing oxidative stress and enhancing epithelial-endothelial transition in diabetic wounds.

Key Points

  • Platelet-rich plasma significantly enhances healing, reducing oxidative stress in diabetic wounds.
  • Therapeutic effects include modulation of reactive oxygen species and boosting angiogenesis.
  • This hypothesis examines mechanisms like mitochondrial transfer and cellular signaling interactions.
  • Effective application of platelet-rich plasma could impact diabetic wounds and related oxidative stress conditions.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23d54b1d3bfb60eff85https://doi.org/10.3389/fbioe.2025.1623780
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancing Diabetic Wound Care with Platelet Rich Plasma: A Systematic Review of Mechanisms and Therapeutic Potential2025 · 1 citations
  2. 2Mechanism of Platelet‐Rich Plasma in Promoting Diabetic Wound Healing via the PI3K/AKT Signaling Pathway to Regulate Collagen Synthesis and Angiogenesis2026 · 3 citations
  3. 3Platelet-Rich Plasma for Wound Healing in Diabetic Patients2025
  4. 4THE THERAPEUTIC POTENTIAL OF PLATELET- RICH PLASMA AND/OR MESENCHYMAL STEM CELLS ON DIABETIC WOUND HEALING: HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY2024
  5. 5A Comparative Study on the Effect of PRP in Healing Diabetic Foot Ulcers Compared to Standard Treatment in Diabetic Patients: A Randomized Clinical Trial Study2026 · 2 citations