Observational analysis demonstrated selective mono- and diaminations in 2,6-dibromopyridine, highlighting novel ligands for metal complexes.
Selective mono- or diaminations of 2,6-dibromopyridine were performed using microwave irradiation with water as solvent in 2-2.5 h. The only significant difference between the syntheses was the inclusion of K2CO3 as base and CuI/DMPAO catalyst for the diaminations. The mono- and diaminations had approximately 7 and 2 g isolated yields, respectively. The monoaminated bromopyridines were attached to a TREN scaffolding molecule yielding novel ligands to support extended metal atom chain complexes.
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Underwood et al. (2025) studied this question.
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