Reversible single-crystal-to-single-crystal phase transition of Nirmatrelvir

Dier Shi; Jiyong Liu; Shuna Liu; Yibin Wang; Kaxi Yu; Xiurong Hu

doi:10.1039/d5ce00705d

January 1, 2025CrystEngComm

Reversible single-crystal-to-single-crystal phase transition of Nirmatrelvir

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Key Points

The reversible phase transition showcases distinct polymorphs of Nirmatrelvir, enhancing its structural complexity.
Temperature-induced changes resulted in two unique forms of Nirmatrelvir, characterized through X-ray analysis.
Employing single-crystal X-ray techniques facilitated the detailed examination of the Nirmatrelvir polymorphs.
These findings highlight the importance of phase transitions in understanding the properties of Nirmatrelvir.

Implication

Transformation reveals two polymorphs of Nirmatrelvir, indicating significant structural changes.

Abstract

Reversible single-crystal-to-single-crystal (SCSC) transformation induced by temperature was found for Nirmatrelvir, resulting in two polymorphs of Nirmatrelvir (Form 1 and Form 4). Their structures were characterized using variable-temperature single-crystal X-ray...

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Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/68c1c24454b1d3bfb60f02ed https://doi.org/10.1039/d5ce00705d

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Reversible single-crystal-to-single-crystal phase transition of Nirmatrelvir

Key Points

Implication

Abstract

Discussion

Cite This Study

Reversible single-crystal-to-single-crystal phase transition of Nirmatrelvir

Key Points

Implication

Abstract

Discussion

Cite This Study

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