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September 10, 2025Frontiers in ImmunologyOpen Access

Ferroptosis and gastric cancer: from molecular mechanisms to clinical implications

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Ferroptosis sensitivity in gastric cancer cells is significantly influenced by abnormalities in iron metabolism.
Ferroptosis inducers can enhance chemotherapy sensitivity, potentially reversing treatment resistance.
Targeting ferroptosis-related pathways effectively inhibits gastric cancer tumor growth and metastasis.
The clinical application of ferroptosis in gastric cancer necessitates careful consideration of its potential risks to normal tissues.

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This article uncovers how ferroptosis affects gastric cancer cell metabolism and resistance to therapy, suggesting new treatment strategies.

Zhao et al. (2025) studied this question.

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This article uncovers how ferroptosis affects gastric cancer cell metabolism and resistance to therapy, suggesting new treatment strategies.