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Case report highlights severe purpura fulminans in a patient with chronic liver disease, suggesting timely intervention can reduce mortality.
Purpura fulminans is a severe thrombotic condition and hematologic emergency marked by disseminated intravascular coagulation and endovascular thrombosis. Timely recognition and treatment are crucial to reduce its high morbidity and mortality. This condition is linked to significant acquired deficiencies in protein C and dysfunction in the protein C-thrombomodulin pathway. Management involves treating the underlying infection, aggressive anticoagulation, and substantial transfusion support to correct deficiencies in natural anticoagulant proteins. We present a case of acute infectious Purpura fulminans with disseminated intravascular coagulation due to pneumonia in a middle-aged male with advanced chronic liver disease.
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Keerthisinghe et al. (2025) studied this question.
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