Toxicological and Phytochemical Studies of an Aqueous Extract of Lophira lanceolata (Ochnaceae) Leaves in Mus Musculus (Muridae) Mice of the Swiss Homogeneous Parent Stock

Lophira lanceolata is a plant commonly used in traditional African medicine to treat several diseases. The qualitative phytochemical study, carried out using the methods described in the work of Méa et al (2017), using an aqueous extract of dried Lophira lanceolata leaves, revealed the presence of sterols, polyphenols, flavonoids, saponosides, quinone compounds, alkaloids and gallic tannins, which are believed to be responsible for certain pharmacological effects on diseases. The study of the acute toxicity of this extract in mice, at doses ranging from 150 to 1000 mg/kg b.w., determined the LD50 values to be 375 and 439 mg/kg b.w., obtained respectively by the Dragstedt and Lang calculation method and the Miller and Tainter graphical method. According to Diezi's classification (1989), this substance is highly toxic when administered intraperitoneally.