Analysis reveals circRNA influences cell proliferation and drug resistance in ovarian cancer, suggesting it as a therapeutic target.
As a common malignant tumor of female reproductive system, ovarian cancer has a high morbidity and mortality, and most patients have reached the advanced stage when diagnosed. In recent years, circular RNA (circRNA) has attracted much attention in ovarian cancer research due to its unique structural and functional properties. This study focused on the expression profile, function (covering cell proliferation, apoptosis, migration, invasion, drug resistance, etc.) and regulatory molecular mechanisms (including and.) of circRNA in ovarian cancer miRNA, protein interactions, and regulation of gene transcription) and prospects as potential therapeutic targets (such as interfering expression, enhancing function, combination therapy and other strategies and advantages). Through high-throughput sequencing, bioinformatics analysis and a variety of experimental verification methods, the role of ovarian cancer in the occurrence and development of ovarian cancer is deeply explored, aiming to provide a basis for the analysis of the pathogenesis of ovarian cancer, and to develop a new direction for the development of novel treatment strategies and improve the prognosis of patients.
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Xiaoen Huang (2025) studied this question.
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