Global perspectives on non-invasive prenatal testing: Implementation, ethics and policy

Non-invasive prenatal testing (NIPT) offers a highly sensitive and specific method for screening fetal chromosomal abnormalities using cell-free fetal DNA from maternal plasma. This systematic review examined global implementation strategies, highlighting clinical, ethical and policy-related barriers and facilitators. NIPT is well-integrated in high-resource settings, while cost and regulatory issues limit access in lower-income countries. Ethical implementation requires informed consent, equitable access and continuous policy evaluation. Findings provide key recommendations for global healthcare systems integrating NIPT.