Seroprevalence of TTIs and its association with ABO and Rh blood groups among blood donors

Transfusion-transmitted infections (TTIs) such as HIV, HBV, HCV, syphilis, and malaria pose significant risks to blood safety. Therefore, it is of interest to assess the seroprevalence of TTIs and their association with ABO/Rh blood groups among 30,335 blood donors. Data from 30,335 donations, with 1,843 reactive units, were analyzed demographically. Overall TTI seroprevalence was 6.08%. O Negative showed the highest reactive rate (9.41%, OR=1.62, 95% CI: 1.14-2.30), followed by B Positive (7.06%, OR=1.26, 95% CI: 1.14-1.39). AB Positive had the lowest rate (4.28%, OR=0.66, 95% CI: 0.56-0.78). A significant association was confirmed (χ2=53.9, df=7, p<0.0001). O Negative and B Positive blood groups are strongly associated with higher TTI seroprevalence, while AB Positive shows lower risk. Thus, targeted screening for high-risk groups could enhance blood safety.