Randomized controlled trial compared stone expulsion with tamsulosin and silodosin in ureterolithiasis patients, indicating silodosin is more effective.
Introduction: The most common urological disorder is ureterolithiasis that sometimes needs correction to alleviate symptoms and encourage stone release. The results of medical expulsive therapy (MET) with alpha-blockers such as tamsulosin and silodosin treatment are promising in distal ureteric stones. Objective: The purpose of this study was to aim to compare the effectiveness of tamsulosin and silodosin in patients with a ureterolith in a tertiary care hospital when it comes to stone expulsions. Material and Methods: This was conducted and carried out as a randomized controlled trial at the department of Urology, KRL Hospital Islamabad, 1st November, 2024 to 30th April, 2025. A random number of 180 patients were divided into two groups; Group A was given tamsulosin 0.4 mg, and Group B was diagnosed with silodosin 8 mg after every day in two weeks. Follow up of CT KUB was carried at day 14 as an evaluation of stone expulsion. Results: Stone expulsion was much more in silodosin group (85.6) than in tamsulosin group (67.8%) (p = 0.006). Conclusion: Compared to tamsulosin, silodosin can facilitate the removal of distal ureteric stone.
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Habib et al. (2025) studied this question.
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