Synthesis, Characterization, Molecular docking of some Hydrazone derived from Isobutyric acid

In this work, isobutyric acid was converted to ethyl isobutyrate by reacting isobutyric acid in 5 ml H2SO4 and absolute ethanol. Ester has been converted to hydrazide by reacting with hydrazine in absolute ethanol, and finally, the hydrazones formed from the hydrazide interaction with substituted aldehyde were prepared. The aim of evaluating their ability to interact with the 8C7Y protein, which represents the crystal structure of the TYRP1 protein (Tyrosinase-related). Its disorders are associated with skin pigmentation and melanoma. The prepared compounds were diagnosed by physical methods, spectroscopic methods, using infrared spectrum and nuclear magnetic resonance of the proton, as well as the completion of the reaction, and confirmed purity the compounds by thin-layer chromatography. The aim of preparing these compounds is to study molecular docking.