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Secondary cancer risks after breast radiotherapy: A dose-response-based comparative review across modern techniques

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Proton therapy shows the lowest secondary cancer risks, especially for the heart, lungs, and esophagus.
Analysis across four radiotherapy techniques revealed significant differences in risks associated with secondary malignancies.
Younger patients have a higher risk of secondary cancers, emphasizing customized treatment planning needs.
Study synthesizes data from 24 studies, providing a comprehensive risk overview for tailored radiotherapy.

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Review identifies optimal radiotherapy techniques and dose thresholds for secondary malignancies, suggesting implications for patient safety.

Derafa et al. (2025) studied this question.

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Review identifies optimal radiotherapy techniques and dose thresholds for secondary malignancies, suggesting implications for patient safety.