Serum Leptin Level in Postmenopausal Breast Cancer With or Without Lymph Node Involvement - A Retrospective Observational Study

Background: One of the main causes of illness and death for postmenopausal women is breast cancer, with lymph node involvement serving as a critical prognostic factor. This study aimed to evaluate serum leptin levels in postmenopausal breast cancer patients with and without lymph node involvement, to explore its potential as a biomarker for disease progression An observational study was conducted on Methods: 60 postmenopausal breast cancer patients, categorized into two groups based on lymph node involvement. Serum leptin levels were measured using enzymelinked immunosorbent assay (ELISA). Statistical analyses, including t-tests and ANOVA, were used to compare leptin levels between the groups. Patients with lymph node involvement exhibited significantly higher serum Results: leptin levels compared to those without lymph node involvement (p < 0.05). These findings suggest that leptin may be associated with increased aggressiveness and metastatic potential in breast cancer. The study suppor Conclusions: ts the role of leptin as a potential biomarker in breast cancer prognosis, particularly in relation to lymphatic metastasis. Further research is required to elucidate the mechanistic pathways linking leptin and lymph node involvement, which may provide opportunities for therapeutic targeting in breast cancer management