Functionalized Selenium Nanoparticles with Baicalin-Myricetin with Neuroprotective Effect for Alzheimer's Disease

Background: AD disease involves deposition of Aβ amyloid in the mitochondria of cells, reducing consumption of glucose by neurons reducing enzyme functions. Contemporary drugs therapy for AD are unable to alleviate this disease; since in the short term it only produced symptomatic alleviation, thus is necessary to develop new drugs with curative effects. Objective: To determine the neuroprotective effect of flavonoids combined with selenium nanoparticles (EM@Se). Methods: Was suc¬cessfully synthesized selenium nanoparticles of Baicalin-Myricetin, characterized using different techniques: UV/vis, Fourier-transform infrared spectroscopy, transmission electron microscopy, DTS, energy dispersive X-ray, vitro drug release, cytotoxicity and in vivo in AD induced by AlCl3. Results: EM@Se showed optimum particle size (94.52 nm), polydispersity index (0.153), and zeta potential (−-30.3 mv) with high entrapment efficiency (88. 7%) NPs achieve significantly maintain EM in vitro release, possesses low cytotoxicity in RAW264.7 macrophage cells. In vivo experiments restore cognitive function to the normal level, reducing hippocampal oxidative damage and decrease Aβ amyloid in plasma. Conclusion: This study provides evidence of the neuroprotective effects of flavonoids combined with nanoparticles.