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September 10, 2025Science AdvancesOpen Access

Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules

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Authors

MAMahla AsghariIndiana University Indianapolis ASAngela R. SaboIndiana University School of Medicine DBDaria BarwinskaIndiana University School of Medicine

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Implication

Integration of spatial protein imaging and transcriptomics tracks regenerative potential in proximal tubules, highlighting key markers THY1 and PROM1.

Key Points

Proximal tubular epithelial cells express THY1, linking it to regenerative potential in kidney tissues.
In kidney disease, THY1 expression decreases while PROM1 emerges, indicating failed repair processes.
An analytical pipeline combines spatial protein imaging with RNA expression to explore kidney tubule subpopulations.
THY1 and PROM1 interplay in proximal tubules serves as a timeline for kidney disease progression.

Cite This Study

Asghari et al. (2025) studied this question.

synapsesocial.com/papers/68c1c64554b1d3bfb60f2852 https://doi.org/10.1126/sciadv.adv8918

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Implication

Integration of spatial protein imaging and transcriptomics tracks regenerative potential in proximal tubules, highlighting key markers THY1 and PROM1.

Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules

Discussion

Member takes

Implication

Key Points

Cite This Study

Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules

Discussion

Member takes

Implication

Key Points

Cite This Study

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