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This is a Systematic Review study.

September 10, 2025Pharmacogenomics

Genetic polymorphism associated with non-response to therapy in inflammatory bowel disease patients: a review

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This review highlights genetic polymorphisms linked to treatment non-response in IBD patients, suggesting predictive tools for personalized care.

Genetic polymorphisms significantly impact treatment non-response in inflammatory bowel disease (IBD), affecting drug efficacy.
Key findings connect TNFα, TNFRSF1A, and TNFRSF1B polymorphisms to reduced effectiveness of anti-TNFα therapies.
Systematic literature review across databases identified relevant studies, revealing key genetic markers associated with drug responses.
Understanding these genetic markers suggests a path toward personalized treatment strategies, improving IBD patient outcomes.

Jegathesan et al. (2025) studied this question.

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This review highlights genetic polymorphisms linked to treatment non-response in IBD patients, suggesting predictive tools for personalized care.