Application Research and Comparative Analysis of Large Language Model-Assisted Lesson Plan Development for Rare Breast Diseases (Preprint)

BACKGROUND Rare breast diseases are infrequently encountered in clinical training, leading to gaps in medical students’ knowledge. Large Language Models (LLMs) show promise in assisting educators, particularly for complex topics like rare diseases where standardized teaching materials are scarce. OBJECTIVE This study aims to evaluate and compare the capabilities of prominent LLMs in generating lesson plans for rare breast diseases targeted at clinical medical students. METHODS Ten representative rare breast diseases were selected based on prior bibliometric analysis and expert consensus. Four LLMs - ChatGPT-4o, Grok3, Deepseek R1, and Doubao - were prompted in Chinese to produce structured teaching plans. Three experienced breast surgery teaching faculty evaluated the generated lesson plans using a standardized score (0-5 points) across six dimensions: Generation Capability, Medical Accuracy, Completeness, Readability, Applicability, and Interactivity. Quantitative scores were compared statistically. RESULTS All LLMs successfully generated lesson plans, but with significant differences across all evaluated dimensions (P < 0.001). Deepseek consistently achieved the highest mean scores in all 6 dimensions. ChatGPT ranked second, also demonstrating strong performance, particularly in Generation Capability and Completeness. Grok3 and Doubao showed moderate performance, with Doubao scoring relatively higher in Readability and Accuracy, while Grok3 performed better in Applicability and Interactivity compared to Doubao. CONCLUSIONS LLMs, particularly advanced models like Deepseek and ChatGPT, demonstrate significant potential in assisting the generation of high-quality lesson plans for rare breast diseases, while variability in quality and occasional inaccuracies necessitate expert review. Integration of LLM-generated materials into medical curricula holds promise for enhancing rare disease education.