Whole-body cryotherapy for mental health and cognitive function: A potential therapy for CFS and long COVID?

Aim: To present the potential role of whole-body cryotherapy (WBC) in improving mental health and cognitive function in patients with Chronic Fatigue Syndrome (CFS) and Long COVID Syndrome (LCS), based on current scientific evidence. Materials and Methods: A review of international literature from the last decade concerning the application of WBC in patients with CFS and LCS was conducted. Sources included randomized controlled trials, clinical case reports, and systematic reviews focusing on mental health, cognitive outcomes, and physiological mechanisms associated with whole-body cryotherapy. Emphasis was placed on mechanisms involving neuroinflammation, oxidative stress, and autonomic regulation. Conclusions: WBC shows promise as an adjunctive, non-pharmacological intervention for reducing fatigue, alleviating depressive symptoms, and improving cognitive function in CFS and LCS. Its therapeutic potential is linked to autonomic and neuroendocrine modulation, reduction of inflammation, and enhanced antioxidant capacity. While existing studies support WBC’s safety and short-term efficacy, further clinical trials are necessary to standardize treatment protocols and assess long-term benefits across diverse patient populations.