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September 10, 2025International Journal of NanomedicineOpen Access

The Impact of Using Different Cationic Polymers on the Formation of Efficient Lipopolyplexes for pDNA Delivery

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Authors

GAGiulia AnderluzziTMTasnim MohamedGMGiorgia Moschetti

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Overview

This study demonstrates superior transfection efficiency with lipopolyplexes in gene delivery, indicating the importance of cationic polymer type.

Key Points

  • Lipopolyplexes demonstrated effective DNA delivery with optimal pDNA, cationic polymer, and lipid ratios.
  • Plasmid DNA complexed with cationic polymers showed negligible in vitro toxicity and improved protein expression.
  • Polymeric composition significantly influenced lipopolyplex structure, affecting endosomal escape and transfection efficiency.
  • PEI-based lipopolyplexes achieved the highest endosomolytic activity and transfection rates among the formulations.

Cite This Study

Anderluzzi et al. (2025) studied this question.

synapsesocial.com/papers/68c1c9eb54b1d3bfb60f3785https://doi.org/10.2147/ijn.s513568
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