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September 10, 2025Bone ReportsOpen Access

Lifetime follow-up of an adult patient with pediatric-onset hypophosphatasia complicated with advanced chronic kidney disease

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Authors

MSMaria SääfKarolinska Institutet SBSigríður BjörnsdóttirReykjavík University MHMathias HaarhausKarolinska University Hospital

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Implication

Case report highlights skeletal complications in a patient with hypophosphatasia and chronic kidney disease, suggesting teriparatide may aid bone health.

Key Points

The patient experienced progressive skeletal complications due to hypophosphatasia and chronic kidney disease.
Treatment with teriparatide showed improved mineralization and reduced pain over a nine-month period.
Bilateral hip fissures led to a total hip replacement, indicating severe skeletal issues linked to HPP.
Kidney transplantation appears to improve bone health outcomes in patients with hypophosphatasia and advanced chronic kidney disease.

Cite This Study

Sääf et al. (2025) studied this question.

synapsesocial.com/papers/68c1c9f454b1d3bfb60f3afc https://doi.org/10.1016/j.bonr.2025.101872

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Implication

Case report highlights skeletal complications in a patient with hypophosphatasia and chronic kidney disease, suggesting teriparatide may aid bone health.

Lifetime follow-up of an adult patient with pediatric-onset hypophosphatasia complicated with advanced chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Lifetime follow-up of an adult patient with pediatric-onset hypophosphatasia complicated with advanced chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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