Observational analysis shows dietary fat and sugar worsen neurodegeneration in obesity, suggesting pathways to Alzheimer's disease.
Background The global incidence of obesity and metabolic disorders has been associated with alterations in the central nervous system, prominently featuring increased oxidative stress and heightened production of amyloid beta peptide (AB), stemming from mitochondrial dysregulations, which potentially contribute to the onset of neurodegenerative disorders like Alzheimer disease.
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Gamas et al. (2025) studied this question.
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