The impact of high-sugar diets on central nervous system disorders: mechanisms, pathogenesis, and dietary implication

Background Excessive sugar consumption has paralleled the global rise in obesity, type 2 diabetes mellitus (T2DM), and related metabolic disorders. High-sugar diets directly contribute to weight gain, insulin resistance, and chronic hyperglycemia, which drive cardiovascular complications and systemic inflammation through advanced glycation end products (AGEs) and oxidative stress. Emerging evidence highlights their critical role in the pathogenesis of central nervous system (CNS) disorders, including Alzheimer's disease, Parkinson's disease, and stroke, likely mediated through obesity-associated chronic inflammation, T2DM-driven blood-brain barrier dysfunction, and neuroinflammation.