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September 10, 2025NatureOpen Access

Quantitative imaging of lipid transport in mammalian cells

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Authors

JIJuan M. Iglesias‐ArtolaMax Planck Institut für ZellbiologieKBKristin BöhligMax Planck Institute of Molecular Cell Biology and GeneticsKSKai SchuhmannMax Planck Institute of Molecular Cell Biology and Genetics

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Overview

Observational analysis reveals non-vesicular lipid transport pathways in mammalian cells, suggesting a crucial role in lipid sorting.

Key Points

  • Directional non-vesicular lipid transport is responsible for fast, species-selective lipid sorting, contrasting with slow vesicular trafficking.
  • Quantification using ultra-high-resolution mass spectrometry showed that non-vesicular transport dominates organelle distribution of lipids.
  • Genetic perturbations demonstrated the coupling between energy-dependent lipid flipping and non-vesicular transport mechanisms.
  • This study provides a quantitative map of retrograde lipid flux, enhancing understanding of lipids in cell biology and disease.

Cite This Study

Iglesias‐Artola et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2e54b1d3bfb60f41d0https://doi.org/10.1038/s41586-025-09432-x
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