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September 10, 2025Annals of Surgical OncologyOpen Access

Additional Axillary Disease After Neoadjuvant Chemotherapy for Patients with Clinically Node-Negative but Sentinel Node-Positive Disease

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Authors

SJSandra JensenTTTove Filtenborg TvedskovTBT. Bechmann

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Overview

Retrospective analysis shows risk factors for additional axillary disease in sentinel node-positive patients, suggesting selective ALND may be feasible.

Key Points

  • Additional axillary disease was found in 32% of patients after neoadjuvant chemotherapy, indicating significant risk factors exist.
  • The multivariable model highlighted that SLN metastatic deposit size and extracapsular extension are critical predictors for additional axillary disease.
  • Isolated tumor cells in sentinel nodes resulted in only 11% risk of additional disease at axillary lymph node dissection.
  • Other tumor characteristics, such as clinical T-stage and multifocality, may influence the individualized approach to ALND.

Cite This Study

Jensen et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2e54b1d3bfb60f41ebhttps://doi.org/10.1245/s10434-025-18045-7
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