Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025BioScience TrendsOpen Access

APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications

View Full Paper
Ask AI
Bookmark
Share

Authors

JCJiajie ChenSZShuoyan ZhaoYZYingying Zhou

Discussion

Loading...

Member takes

Overview

This review highlights lipid metabolism changes in microglia in Alzheimer's disease, revealing APOE4's role and the implications for neuroinflammation.

Key Points

  • Microglial reprogramming by APOE4 impairs lipid metabolism and phagocytosis linked to AD.
  • In Alzheimer’s disease, disrupted lipid metabolism and neuroinflammation worsen cognitive decline.
  • The review provides insights into the pathways activated by APOE4 in microglial dysfunction.
  • Emerging therapeutic strategies focus on targeting lipid metabolic disturbances to mitigate AD effects.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2e54b1d3bfb60f42e7https://doi.org/10.5582/bst.2025.01148
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia2024 · 26 citations
  2. 2ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer’s Disease via Epigenetic Reprogramming of the Asxl1/LXRα–H3K4me3 Axis2026 · 1 citations
  3. 3APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia2024 · 539 citations
  4. 4APOE-Targeted Therapeutics for Alzheimer's Disease2025
  5. 5Apolipoprotein E Deficiency Impairs Human Microglial Proliferation Accompanied by Elevated Cellular Oxidative Stress2026