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September 10, 2025BMC NeuroscienceOpen Access

Hybrid molecule SA-10 and its PLGA nanosuspension protect human and rodent retinal ganglion cells against neuronal injury

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Authors

JPJennifer H. PhamWZWei ZhangKLKomarova Le

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Overview

Observational analysis improved retinal ganglion cell survival and function in models of oxidative stress, suggesting a new treatment for glaucoma.

Key Points

  • SA-10-NP improved PERG amplitudes by 112.96% in females, confirming its neuroprotective properties.
  • Oxidative stress reduction was significant, with ROS levels decreasing by 25.9% in primary RGCs exposed to ET-3.
  • Treatment with SA-10 showed upregulation of oxidative stress markers NRF2 and HMOX1 in human retinal explants.
  • Sustained drug delivery from SA-10-NP could provide a novel therapeutic strategy for glaucomatous optic neuropathy.

Cite This Study

Pham et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2e54b1d3bfb60f43c2https://doi.org/10.1186/s12868-025-00971-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuroprotective and Anti-Inflammatory Activities of Hybrid Small-Molecule SA-10 in Ischemia/Reperfusion-Induced Retinal Neuronal Injury Models2024 · 5 citations
  2. 2Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model2026
  3. 3rhNGF shows neuroprotective efficacy by counteracting oxidative stress and neuroinflammation in a glaucoma mouse model2026
  4. 4Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery2026
  5. 5The 5-HT1A receptor antagonist WAY-100635 maleate promotes retinal ganglion cell differentiation and protects the retino-visual circuits2026