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August 9, 2026Bioactive MaterialsOpen Access

Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model

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Authors

HRHong RenChinese Academy of SciencesYWYukun WuCentral South UniversityYYYang YangShanghai University of Traditional Chinese Medicine

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Implication

Randomized trial demonstrates improved RGC survival in a glaucoma model, indicating a potential neuroprotective strategy.

Key Points

  • To develop a hydrogel system that modulates RGC necroptosis and oxidative stress in glaucoma.
  • Created a ROS-responsive hydrogel (PD@Gel) with Plantainoside D-loaded nanoparticles within hyaluronic acid precursor.
  • Conducted intravitreal injections to assess efficacy in a murine retinal ischemia-reperfusion model.
  • Evaluated mitochondrial membrane potential and necroptotic signaling in vitro.
  • In vitro treatment preserved mitochondrial membrane potential and reduced necroptotic signaling.
  • In vivo injection improved RGC survival and showed reduced necroptosis markers (p-RIPK1/p-MLKL).
  • Partial restoration of visual function was observed in the murine model.

Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/6a782cfa2e1896536c83fbechttps://doi.org/10.1016/j.bioactmat.2026.07.012
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