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September 10, 2025Nucleosides Nucleotides & Nucleic AcidsOpen Access

Analysis of differentially expressed genes and biological information between rheumatoid arthritis and osteoarthritis based on the GEO database

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Authors

ZLZeli LiGuangzhou University of Chinese MedicineGLGuohai LiJiangsu UniversityQXQianwen Xiong

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Overview

Bioinformatics analysis shows 665 DEGs in rheumatoid arthritis and osteoarthritis, indicating possible mechanisms. Key pathways include immune response and signal transduction.

Key Points

  • A total of 665 differentially expressed genes were identified, including 324 upregulated and 341 downregulated.
  • Key biological processes enriched among DEGs include immune response and inflammatory response, highlighting their roles in rheumatoid arthritis.
  • GO and KEGG enrichment analyses revealed significant pathways related to cytokine interaction and apoptosis, indicating important biological roles.
  • Ten core genes were identified, with CD3D, CD27, KLRB1, CCL5, and GZMB showing significant correlation with rheumatoid arthritis development.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc3754b1d3bfb60f4594https://doi.org/10.1080/15257770.2025.2540414
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Screening and identification of key biomarkers in Rheumatoid arthritis: Evidence from bioinformatic analysis2024
  2. 2Analysis of common differential gene expression in synovial cells of osteoarthritis and rheumatoid arthritis2024 · 7 citations
  3. 3Identification of key pathways and biomarkers in rheumatoid arthritis synovial tissue through comprehensive transcriptomic integration2025 · 2 citations
  4. 4Bioinformatics analysis identifies a novel 4-gene signature associated with immune cell infiltration in osteoarthritis: a combined bioinformatics and experimental validation study2026
  5. 5Identification and validation of immune-related genes in osteoarthritic synovial fibroblasts2024