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Total synthesis achieved for muraymycin A1, employing a novel protecting group strategy and advanced alkynylation techniques.
Muraymycin A1 (MA1) is the most structurally complex member of its family, characterized by a 13-(1-hydroxyguanidino)tridecanoate moiety. Owing to the acid-labile hydroxyguanidino group, its chemical synthesis demands a sophisticated protecting group strategy. We accomplished the total synthesis of MA1 through highly stereoselective alkynylation and Strecker reactions, employing a (4,4'-bisfluorophenyl)methoxymethyl (BFPM)-protected uridine derivative.
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Mitachi et al. (2025) studied this question.
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