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September 10, 2025AndrologyOpen Access

From classification to clinical impact: The APHRODITE criteria and hormonal therapy for idiopathic male infertility

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Observational analysis reveals hormonal therapy improves outcomes in male infertility, suggesting new treatment paths.

Hormonal therapy enhances spermatogenesis in men with idiopathic infertility and the APHRODITE criteria guide treatment.
Men with classical hypogonadotropic hypogonadism see restoration of spermatogenesis in up to 90% of cases with gonadotropin therapy.
The APHRODITE framework categorizes men with male infertility into five groups based on hormonal and seminal parameters.
Prospective studies are needed to validate findings and refine treatment strategies for optimizing hormonal therapy.

Sandro C. Esteves (2025) studied this question.

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