New findings uncover how Drosophila Rab39 affects synaptic autophagy, suggesting a link to dysregulated proteostasis in neurodegenerative diseases.
Autophagy dysregulation at the neural synapse is a hallmark of Parkinson's disease and has diverse molecular origins. New research in The EMBO Journal investigates the role of Drosophila Rab39, and uncovers a system for compartmentalized regulation of synaptic autophagy, with implications for our understanding of dysregulated synaptic proteostasis as observed in neurodegenerative diseases.
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Huang et al. (2025) studied this question.
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