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September 10, 2025Communications BiologyOpen Access

Glucosylsphingosine affects mitochondrial function in a neuronal cell model

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Authors

VNValeria NikolaenkoSRSreekanth Vootukuri ReddySESimon Eaton

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Overview

Proteomic analysis reveals glucosylsphingosine disrupts mitochondrial function and glycolysis in Gaucher disease, indicating a role in disease pathology.

Key Points

  • Glucosylsphingosine reduces ATP production and increases oxidative stress in neuronal cells.
  • Functional analysis shows negative effects on the TCA cycle and glycolysis due to glucosylsphingosine.
  • Proteomics highlights glucosylsphingosine's binding to tubulin alpha, increasing ubiquitination of α and β tubulins.
  • Supranormal glucosylsphingosine levels may contribute to the pathology of Gaucher disease and associated conditions.

Cite This Study

Nikolaenko et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc4754b1d3bfb60f4d44https://doi.org/10.1038/s42003-025-08684-7
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