What type of study is this?

September 10, 2025Fluids and Barriers of the CNSOpen Access

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

View Full Paper

Ask AI

Bookmark

Authors

GBGillian BonviciniUppsala University SSS. Gojendra SinghJSS Academy of Higher Education and Research LSLisa SandersjööBioArctic Neuroscience (Sweden)

Discussion

Member takes

Implication

Experimental analysis shows increased brain uptake of bispecific antibodies in mouse models with Aβ pathology, indicating improved diagnostic potential.

Key Points

Stronger transferrin receptor affinity results in significantly increased brain uptake of bispecific antibodies, enhancing diagnostic capabilities.
The highest affinity antibody (10 nM) effectively differentiated between wild-type and Aβ pathology in mice, demonstrating its potential usefulness in immunoPET.
In vivo pharmacokinetic evaluations indicated that the affinity variations affect brain delivery, crucial for developing future diagnostic tools.
This study highlights the importance of optimizing transferrin receptor binding affinities for better delivery of diagnostic agents targeting intrabrain Aβ.

Cite This Study

Bonvicini et al. (2025) studied this question.

synapsesocial.com/papers/68c1ce5d54b1d3bfb60f53fd https://doi.org/10.1186/s12987-025-00693-2

View Full Paper

Ask AI

Bookmark

Implication

Experimental analysis shows increased brain uptake of bispecific antibodies in mouse models with Aβ pathology, indicating improved diagnostic potential.

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Discussion

Member takes

Implication

Key Points

Cite This Study

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider