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September 10, 2025Immunity & AgeingOpen Access

Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease

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Modulating systemic inflammation may significantly reduce the risk of Alzheimer's disease onset and progression.
Evident pathways like the NLRP3 inflammasome and TREM2 show promise as therapeutic targets in Alzheimer’s disease.
Systemic immune disturbances, including infections and chronic diseases, may act as critical risk factors for Alzheimer’s.
The review emphasizes the need for early diagnosis and intervention to mitigate Alzheimer's disease risk.

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This review highlights how systemic inflammation affects neuroinflammation in Alzheimer's disease, suggesting immune targets.

Bayraktaroglu et al. (2025) studied this question.

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